Flexeril Oral Reviews and User Ratings: Effectiveness, Ease of Use, and Satisfaction

The rationale for the study was that bedtime administration of VLD CBP would have a more acceptable side effect profile than higher doses administered during the day2,3,4,5,6,7,8, and yet might show effects on FM symptoms. Drug comparisons between cyclobenzaprine and methocarbamol in terms of side effects do not reveal many differences. Both medications can cause adverse effects such as dizziness, drowsiness, headache, nausea, and fatigue. Cyclobenzaprine tends to cause more drowsiness than methocarbamol. Also, cyclobenzaprine can cause dry mouth because it has anticholinergic effects. The other dosage form of this medicine is an injection solution into a muscle or into a vein.

  • It’s not considered a dangerous method of getting rid of specific muscular pain.
  • Because of its atropine-like action, FLEXERIL should be used with caution in patients with a history of urinary retention, angle-closure glaucoma, increased intraocular pressure, and in patients taking anticholinergic medication.
  • It makes me sleepy so I only take it at night but unless it is cold, it works well for me.
  • And when cyclobenzaprine and alcohol, opioids, or drugs are used in combination, that risk becomes even higher.

Adverse effects, particularly dizziness and drowsiness, are consistently reported with all skeletal muscle relaxants. The potential adverse effects should be communicated clearly to the patient. Because of limited comparable effectiveness data, choice of agent should be based on side-effect profile, patient preference, abuse potential, and possible drug interactions.

Why do Doctors Prescribe Muscle Relaxers?

Correlation of increased nights of CAPA2+A3(Norm) ≤ 33% with VLD CBP improvements on FM symptoms and sleep EEG measures. CBP was formulated as 1 baclofen flexeril mg capsules, and placebo capsules contained no CBP. Investigators were allowed to adjust dosage throughout the study as tolerability allowed.

Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible. The acute oral LD50 of FLEXERIL is approximately 338 and 425 mg/kg in mice and rats, respectively. The plasma concentration of cyclobenzaprine is increased in the elderly (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Elderly).

Together, these findings show that bedtime treatment with VLD CBP provided benefit to patients with FM by improving symptoms of pain, tenderness, fatigue, and depressed mood. We conclude that cyclobenzaprine is significantly better at relieving back pain than placebo at all times measured. Patients can expect about a 5-fold increase in the odds of experiencing improvement by 14 days and up to 2 SDs of improvement, a moderate effect size. Clinicians will need to treat 3 patients to improve the symptoms of 1. Adverse effects will be common, experienced in more than half of the patients, with 20% experiencing drowsiness.


A post-marketing surveillance program was carried out in 7607 patients with acute musculoskeletal disorders, and included 297 patients treated with FLEXERIL 10 mg for 30 days or longer. The overall effectiveness of FLEXERIL was similar to that observed in the double-blind controlled studies; the overall incidence of adverse effects was less (see ADVERSE REACTIONS). Conclusions Cyclobenzaprine is more effective than placebo in the management of back pain; the effect is modest and comes at the price of greater adverse effects. The effect is greatest in the first 4 days of treatment, suggesting that shorter courses may be better. Studies comparing the relative value of acetaminophen, nonsteroidal anti-inflammatory drugs, and cyclobenzaprine individually and in combination in the treatment of back pain are needed. Cyclobenzaprine (sometimes branded as Flexeril) is an antispasmodic, FDA-approved medication for the treatment of acute musculoskeletal pain (8).

Trazodone Oral: Uses, Side Effects, Interactions, Pictures, Warnings … – WebMD

Trazodone Oral: Uses, Side Effects, Interactions, Pictures, Warnings ….

Posted: Tue, 15 Oct 2019 15:57:51 GMT [source]

Antispastic drugs work at the spinal cord or on specific muscles to reduce muscle tone and involuntary movement. As the name suggests, they treat spasticity, a muscle’s resistance to movement that’s dependent on the speed of movement. Spasticity commonly results from injury to the central nervous system. Examples of conditions involving muscle spasticity include cerebral palsy, multiple sclerosis, and spinal cord injury (1). Baclofen is a common antispastic prescribed to treat these conditions. Potential mechanisms for how bedtime CBP may improve FM symptoms are suggested by work on the sensation and regulation of pain in FM44.

Generic methocarbamol is around $6.25 for 30 tablets of the 500mg dose with a BuzzRx drug discount card. Brand name Robaxin is approximately $95 for 30 tablets of the 750mg dose with a BuzzRx savings card. Generic cyclobenzaprine may be under $0.50 for 30 tablets of the 10mg dose through the BuzzRx discount program.

National Ambulatory Medical Care Survey data suggest that patients presenting with low back pain are commonly given more than 1 treatment.12 Often, acetaminophen is combined with an NSAID or a muscle relaxant. Less commonly, patients are given a narcotic for the first few days of pain. To our knowledge, no studies have been done to determine the optimum combination of treatment modalities.

Back pain and related musculoskeletal disorders can interfere with daily routines, sleep, job performance, and your ability to enjoy your hobbies. A record of all medication dispensed and returned during the study was maintained by the investigators. After even taking the pill a couple of doses even to see if an adjustment period was needed.